Piperaquine phosphate

• CAT Number: I045016
• CAS Number: 85547-56-4
• Molecular Formula: C29H35Cl2N6O4P
• Molecular Weight: 633.51
• Purity: ≥95%
• Synonyms: 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;phosphoric acid
• InChI: InChI=1S/C29H32Cl2N6.H3O4P/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29;1-5(2,3)4/h2-9,20-21H,1,10-19H2;(H3,1,2,3,4)
• InChIKey: KATNPMSTHHZOTK-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl.OP(=O)(O)O

Piperaquine Phosphate（Cat No.:I045016）is a bisquinoline antimalarial agent primarily used in combination therapies to combat multidrug-resistant Plasmodium falciparum malaria. Structurally related to chloroquine, it exerts its antimalarial effects by inhibiting heme detoxification in the parasite’s digestive vacuole. Its phosphate salt form improves solubility and bioavailability. Due to its long half-life, piperaquine provides sustained therapeutic levels, making it well-suited for once-daily dosing regimens. It is commonly paired with dihydroartemisinin in artemisinin-based combination therapies (ACTs). While effective, monitoring is required due to potential QT interval prolongation. Its clinical use is strictly for supervised antimalarial treatment.