For research use only. Not for therapeutic Use.
PIP4K-IN-a131（Cat No.:I015456）is a selective small-molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase (PIP4K), an enzyme regulating phosphoinositide metabolism and signaling. By blocking PIP4K activity, it reduces the conversion of PI(5)P to PI(4,5)P₂, thereby altering pathways involved in cell growth, survival, and stress responses. This compound is particularly useful in studying cancer biology, immune signaling, and metabolic regulation, where phosphoinositide turnover plays a pivotal role. As a chemical probe, PIP4K-IN-a131 enables researchers to dissect lipid kinase functions and evaluate PIP4K as a potential therapeutic target in disease models.
| CAS Number | 2055405-95-1 |
| Synonyms | (Z)-2-(1H-indol-3-yl)-3-isoquinolin-5-ylprop-2-enenitrile |
| Molecular Formula | C20H13N3 |
| Purity | ≥95% |
| IUPAC Name | (Z)-2-(1H-indol-3-yl)-3-isoquinolin-5-ylprop-2-enenitrile |
| InChI | InChI=1S/C20H13N3/c21-11-16(19-13-23-20-7-2-1-6-18(19)20)10-14-4-3-5-15-12-22-9-8-17(14)15/h1-10,12-13,23H/b16-10+ |
| InChIKey | GWWKEWLUVHLNEX-MHWRWJLKSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CN2)/C(=C/C3=CC=CC4=C3C=CN=C4)/C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
