For research use only. Not for therapeutic Use.
PIP-199（Cat No.:I034777）is a small molecule inhibitor known for targeting the FANCM-RMI protein-protein interaction, which plays a role in DNA repair and genome stability. By disrupting this interaction, PIP-199 impairs the function of the Fanconi anemia pathway, sensitizing cells to DNA-damaging agents and contributing to genomic instability in cancer cells. It is used in research exploring mechanisms of DNA repair, synthetic lethality, and cancer therapeutics. PIP-199 helps elucidate the role of FANCM in replication stress response and is a useful probe for studying targeted cancer vulnerabilities.
| CAS Number | 622795-76-0 |
| Synonyms | ethyl 4-[(1-hydroxy-2-phenylindol-3-yl)-pyridin-2-ylmethyl]piperazine-1-carboxylate |
| Molecular Formula | C27H28N4O3 |
| Purity | ≥95% |
| IUPAC Name | ethyl 4-[(1-hydroxy-2-phenylindol-3-yl)-pyridin-2-ylmethyl]piperazine-1-carboxylate |
| InChI | InChI=1S/C27H28N4O3/c1-2-34-27(32)30-18-16-29(17-19-30)26(22-13-8-9-15-28-22)24-21-12-6-7-14-23(21)31(33)25(24)20-10-4-3-5-11-20/h3-15,26,33H,2,16-19H2,1H3 |
| InChIKey | ROTCTSYSZSYNHB-UHFFFAOYSA-N |
| SMILES | CCOC(=O)N1CCN(CC1)C(C2=CC=CC=N2)C3=C(N(C4=CC=CC=C43)O)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
