For research use only. Not for therapeutic Use.
Pin1 Modulator 1 (CAT: I040454) is a targeted small-molecule modulator designed to disrupt β-Catenin function and inhibit the Wnt/β-Catenin signaling pathway. By specifically interacting with β-Catenin, it effectively downregulates Wnt-mediated transcriptional activity, making it a valuable tool for investigating the molecular mechanisms underlying Wnt-driven diseases. Pin1 Modulator 1 is particularly relevant in cancer research, where aberrant Wnt signaling contributes to tumorigenesis, proliferation, and metastasis. Its selective action enables detailed studies of Pin1-β-Catenin interactions and Wnt pathway modulation, supporting drug discovery and therapeutic development for colorectal, liver, and other Wnt-related cancers. Suitable for mechanistic and preclinical studies.
| CAS Number | 301688-74-4 |
| Synonyms | 4-[(5E)-5-(naphthalen-1-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid |
| Molecular Formula | C18H15NO3S2 |
| Purity | ≥95% |
| IUPAC Name | 4-[(5E)-5-(naphthalen-1-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid |
| InChI | InChI=1S/C18H15NO3S2/c20-16(21)9-4-10-19-17(22)15(24-18(19)23)11-13-7-3-6-12-5-1-2-8-14(12)13/h1-3,5-8,11H,4,9-10H2,(H,20,21)/b15-11+ |
| InChIKey | NMYDPSCPARBVHD-RVDMUPIBSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC=C2C=C3C(=O)N(C(=S)S3)CCCC(=O)O |
| Reference | Pin1 Modulator 1 (compound IIb-219) is a targeted small-molecule modulator designed to disrupt β-Catenin function and inhibit the Wnt/β-Catenin signaling pathway. By specifically interacting with β-Catenin, it effectively downregulates Wnt-mediated transcriptional activity, making it a valuable tool for investigating the molecular mechanisms underlying Wnt-driven diseases. Pin1 Modulator 1 is particularly relevant in cancer research, where aberrant Wnt signaling contributes to tumorigenesis, proliferation, and metastasis. Its selective action enables detailed studies of Pin1-β-Catenin interactions and Wnt pathway modulation, supporting drug discovery and therapeutic development for colorectal, liver, and other Wnt-related cancers. Suitable for mechanistic and preclinical studies. |
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