PIN1 inhibitor API-1

• CAT Number: R006448
• CAS Number: 680622-70-2
• Molecular Formula: C15H13F3N6O2
• Molecular Weight: 366.30
• Purity: ≥95%
• Synonyms: N-[[4-[(2-amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]-2,2,2-trifluoroacetamide
• InChI: InChI=1S/C15H13F3N6O2/c16-15(17,18)13(25)20-5-8-1-3-9(4-2-8)6-26-12-10-11(22-7-21-10)23-14(19)24-12/h1-4,7H,5-6H2,(H,20,25)(H3,19,21,22,23,24)
• InChIKey: AQFWAWXGBQPBIA-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CNC(=O)C(F)(F)F)COC2=NC(=NC3=C2NC=N3)N

PIN1 Inhibitor API-1（Cat No.:R006448）is a selective small-molecule antagonist of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1), an enzyme that regulates protein conformation and stability by isomerizing phosphorylated Ser/Thr-Pro motifs. By blocking PIN1 activity, API-1 disrupts oncogenic signaling, reduces cell proliferation, and promotes apoptosis. This compound is a valuable tool for studying protein folding, cell cycle regulation, and tumorigenesis. PIN1 Inhibitor API-1 has shown promise in cancer research, highlighting its potential in therapeutic strategies targeting aberrant PIN1-mediated pathways involved in tumor growth and progression.