For research use only. Not for therapeutic Use.
PIK-75(CAT: I008762) is a potent, reversible inhibitor of DNA-dependent protein kinase (DNA-PK) and the PI3K catalytic subunit p110α, showing IC₅₀ values of 2 nM (DNA-PK), 5.8 nM (p110α), and 76 nM (p110γ). It demonstrates remarkable selectivity, inhibiting p110α over 200-fold more potently than p110β (IC₅₀ = 1.3 μM). PIK-75 effectively disrupts PI3K/AKT signaling, leading to apoptosis and cell cycle arrest in tumor models. Researchers employ PIK-75 in cancer biology to study DNA repair, kinase signaling, and therapeutic resistance mechanisms. Its dual activity on DNA-PK and PI3K makes it a valuable tool for oncology and targeted therapy research.
| CAS Number | 372196-67-3 |
| Synonyms | N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide |
| Molecular Formula | C16H14BrN5O4S |
| Purity | ≥95% |
| IUPAC Name | N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide |
| InChI | InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+ |
| InChIKey | QTHCAAFKVUWAFI-DJKKODMXSA-N |
| SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
