For research use only. Not for therapeutic Use.
Pifusertib hydrochloride (Cat No.:I045083) is a potent, selective, and orally bioavailable inhibitor of AKT kinases, key components of the PI3K/AKT/mTOR signaling pathway that regulates cell growth, survival, and metabolism. By inhibiting AKT1, AKT2, and AKT3, pifusertib suppresses downstream phosphorylation events, leading to reduced tumor cell proliferation and enhanced apoptosis, particularly in cancers with activated PI3K/AKT signaling. It has demonstrated antitumor activity in preclinical models of solid tumors and hematologic malignancies. Pifusertib hydrochloride is under investigation as a targeted therapy for resistant or genetically defined cancers.
| CAS Number | 2930090-28-9 |
| Synonyms | 3-amino-1-methyl-3-[4-(5-phenyl-8-oxa-3,6,12-triazatricyclo[7.4.0.02,6]trideca-1(9),2,4,10,12-pentaen-4-yl)phenyl]cyclobutan-1-ol;hydrochloride |
| Molecular Formula | C26H25ClN4O2 |
| Purity | ≥95% |
| IUPAC Name | 3-amino-1-methyl-3-[4-(5-phenyl-8-oxa-3,6,12-triazatricyclo[7.4.0.02,6]trideca-1(9),2,4,10,12-pentaen-4-yl)phenyl]cyclobutan-1-ol;hydrochloride |
| InChI | InChI=1S/C26H24N4O2.ClH/c1-25(31)14-26(27,15-25)19-9-7-17(8-10-19)22-23(18-5-3-2-4-6-18)30-16-32-21-11-12-28-13-20(21)24(30)29-22;/h2-13,31H,14-16,27H2,1H3;1H |
| InChIKey | JPKYUPVHSPWRNX-UHFFFAOYSA-N |
| SMILES | CC1(CC(C1)(C2=CC=C(C=C2)C3=C(N4COC5=C(C4=N3)C=NC=C5)C6=CC=CC=C6)N)O.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
