For research use only. Not for therapeutic Use.
Picrotoxinin(CAT:M079695) is a naturally occurring sesquiterpene lactone isolated from Anamirta cocculus seeds. It is the active component of picrotoxin, a well-known GABAA_A receptor antagonist. By noncompetitively blocking the chloride channel of GABAA_A receptors, Picrotoxinin induces neuronal excitation, making it a valuable tool for studying inhibitory neurotransmission, ion channel physiology, and seizure mechanisms. It has been widely used in pharmacological and neurotoxicological research to probe GABAergic signaling and evaluate anticonvulsant agents. Due to its potent central nervous system activity, Picrotoxinin is primarily utilized as a research compound in neuroscience, receptor pharmacology, and toxicology studies.
| CAS Number | 17617-45-7 |
| Synonyms | (1R,3R,5S,8S,9R,12S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione |
| Molecular Formula | C15H16O6 |
| Purity | ≥95% |
| IUPAC Name | (1R,3R,5S,8S,9R,12S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione |
| InChI | InChI=1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8-,9-,10-,13-,14-,15+/m1/s1 |
| InChIKey | PIMZUZSSNYHVCU-YKWPQBAZSA-N |
| SMILES | CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
