Picotamide

  • CAT Number: R067013
  • CAS Number: 32828-81-2
  • Molecular Formula: C21H20N4O3
  • Molecular Weight: 376.416
  • Purity: ≥95%
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Picotamide is an antiplatelet drug that inhibits both thromboxane A<sub>2</sub> (TXA<sub>2</sub>) receptors (K<sub>d</sub> = 325 nM) and TXA<sub>2</sub> synthase. It significantly inhibits basal and lipopolysaccharide-stimulated TXA<sub>2</sub> synthesis by rat peritoneal macrophages when used at 0.5 mM. Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.

Catalog Number R067013
CAS Number 32828-81-2
Synonyms

4-methoxy-N1,N3-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

Molecular Formula

C21H20N4O3

Purity 95%
Storage Room temperature
IUPAC Name 4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide
InChI InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChIKey KYWCWBXGRWWINE-UHFFFAOYSA-N
SMILES COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3
Reference

1.Celestini, A. and Violi, F. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc. Health Risk Manag. 3(1), 93-98 (2008).

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