Picotamide is an antiplatelet drug that inhibits both thromboxane A<sub>2</sub> (TXA<sub>2</sub>) receptors (K<sub>d</sub> = 325 nM) and TXA<sub>2</sub> synthase. It significantly inhibits basal and lipopolysaccharide-stimulated TXA<sub>2</sub> synthesis by rat peritoneal macrophages when used at 0.5 mM. Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.
| Catalog Number | R067013 |
| CAS Number | 32828-81-2 |
| Synonyms | 4-methoxy-N1,N3-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide |
| Molecular Formula | C21H20N4O3 |
| Purity | 95% |
| Storage | Room temperature |
| IUPAC Name | 4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide |
| InChI | InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27) |
| InChIKey | KYWCWBXGRWWINE-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3 |
| Reference | 1.Celestini, A. and Violi, F. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc. Health Risk Manag. 3(1), 93-98 (2008). |
