Picotamide

• CAT Number: R067013
• CAS Number: 32828-81-2
• Molecular Formula: C21H20N4O3
• Molecular Weight: 376.416
• Purity: ≥95%
• Storage: Room temperature
• IUPAC Name: 4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide
• InChI: InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
• InChIKey: KYWCWBXGRWWINE-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3

Picotamide is an antiplatelet drug that inhibits both thromboxane A2 (TXA2) receptors (Kd = 325 nM) and TXA2 synthase. It significantly inhibits basal and lipopolysaccharide-stimulated TXA2 synthesis by rat peritoneal macrophages when used at 0.5 mM. Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.

Reference

1.Celestini, A. and Violi, F. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc. Health Risk Manag. 3(1), 93-98 (2008).