Phthalimidoacetyl chloride

• CAT Number: L012506
• CAS Number: 6780-38-7
• Molecular Formula: C10H6ClNO3
• Molecular Weight: 223.61
• Purity: ≥95%
• IUPAC Name: 2-(1,3-dioxoisoindol-2-yl)acetyl chloride
• InChI: InChI=1S/C10H6ClNO3/c11-8(13)5-12-9(14)6-3-1-2-4-7(6)10(12)15/h1-4H,5H2
• InChIKey: RHZBRCQIKQUQHQ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CC(=O)Cl

Phthalimidoacetyl chloride(CAT: L012506) is a reactive acyl chloride derivative featuring a phthalimide-protected aminoacetyl group. It serves as a key intermediate in organic synthesis, particularly in the preparation of α-amino acid derivatives, peptidomimetics, and biologically active small molecules. The phthalimide moiety provides effective nitrogen protection, allowing for selective transformations, while the acyl chloride functionality facilitates efficient coupling with nucleophiles such as amines and alcohols. This compound is widely used in pharmaceutical and agrochemical research, enabling the construction of complex molecular frameworks. Its combination of stability and reactivity makes it a valuable reagent in synthetic and medicinal chemistry.