PhosTAC7

• CAT Number: I044156
• CAS Number: 3016307-75-5
• Molecular Formula: C58H87ClN2O17
• Molecular Weight: 1119.77
• Purity: ≥95%
• Synonyms: [(1R)-1-[3-[2-[2-[2-[2-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
• InChI: InChI=1S/C58H87ClN2O17/c1-7-48(46-41-53(67-4)56(69-6)54(42-46)68-5)57(63)61-24-12-10-17-49(61)58(64)78-50(20-18-44-19-21-51(65-2)52(39-44)66-3)45-15-14-16-47(40-45)77-43-55(62)60-23-26-71-28-30-73-32-34-75-36-38-76-37-35-74-33-31-72-29-27-70-25-13-9-8-11-22-59/h14-16,19,21,39-42,48-50H,7-13,17-18,20,22-38,43H2,1-6H3,(H,60,62)/t48-,49-,50+/m0/s1
• InChIKey: RPIBISHYKGHEDG-YGENRYQBSA-N
• SMILES: CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCCCCCCl

PhosTAC7（Cat No.:I044156）is a bifunctional small molecule designed to induce targeted protein dephosphorylation through proximity-directed phosphatase recruitment. As a phosphatase-targeting chimera (PhosTAC), PhosTAC7 simultaneously binds a phosphatase and a phosphorylated substrate protein, facilitating dephosphorylation without altering protein abundance. This precise modulation of phosphorylation status enables functional studies of phospho-signaling pathways. PhosTAC7 is particularly useful in exploring the dynamic roles of phosphorylation in cellular processes such as signal transduction, cell cycle progression, and oncogenesis. It represents a novel approach in chemical biology for reversibly tuning protein function via post-translational modification control.