For research use only. Not for therapeutic Use.
Phortress (Cat No.:I008749) is an experimental anticancer prodrug developed by the University of Nottingham. It is the lysylamide dihydrochloride salt of 5F 203, a benzothiazole derivative. Upon cellular uptake, Phortress releases 5F 203, which binds to the aryl hydrocarbon receptor (AhR), leading to the induction of cytochrome P450 1A1 (CYP1A1) expression. This metabolic activation produces electrophilic species that form DNA adducts, causing double-strand breaks and apoptosis in sensitive tumor cells. Phortress has demonstrated potent and selective activity against breast, ovarian, and renal carcinomas and is currently undergoing Phase I clinical trials.
| CAS Number | 328087-38-3 |
| Synonyms | (2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide;dihydrochloride |
| Molecular Formula | C20H25Cl2FN4OS |
| Purity | ≥95% |
| IUPAC Name | (2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide;dihydrochloride |
| InChI | InChI=1S/C20H23FN4OS.2ClH/c1-12-10-13(20-25-17-11-14(21)6-8-18(17)27-20)5-7-16(12)24-19(26)15(23)4-2-3-9-22;;/h5-8,10-11,15H,2-4,9,22-23H2,1H3,(H,24,26);2*1H/t15-;;/m0../s1 |
| InChIKey | QZSMNTOCJVVFEU-CKUXDGONSA-N |
| SMILES | CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)[C@H](CCCCN)N.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
