PHGDH-inactive

• CAT Number: I011572
• CAS Number: 1914971-16-6
• Molecular Formula: C17H21N5S
• Molecular Weight: 327.45
• Purity: ≥95%
• Synonyms: N-(4,6-dimethylpyridin-2-yl)-4-pyridin-4-ylpiperazine-1-carbothioamide
• InChI: InChI=1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
• InChIKey: ITLPIAAGIQAGRA-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=CC=NC=C3)C

PHGDH-inactive (Cat No.: I011572) refers to a small-molecule control compound designed to complement PHGDH inhibitors in research studies. PHGDH (phosphoglycerate dehydrogenase) is the first enzyme in the serine biosynthesis pathway, often upregulated in cancer cells to support proliferation and redox balance. While active PHGDH inhibitors block this metabolic flux, PHGDH-inactive serves as a structurally similar but biologically inactive analog. It is used as a negative control to confirm target specificity, ensuring that observed cellular effects are due to PHGDH inhibition.

Reference

[1]. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8):656]. Nat Chem Biol. 2016;12(6):452-458.
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