Phenamil methanesulfonate

• CAT Number: R022228
• CAS Number: 1161-94-0
• Molecular Formula: C13H16ClN7O4S
• Molecular Weight: 401.83
• Purity: ≥95%
• Synonyms: 3,5-diamino-6-chloro-N-(N’-phenylcarbamimidoyl)pyrazine-2-carboxamide;methanesulfonic acid
• IUPAC Name: 3,5-diamino-6-chloro-N-(N'-phenylcarbamimidoyl)pyrazine-2-carboxamide;methanesulfonic acid
• InChI: InChI=1S/C12H12ClN7O.CH4O3S/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6;1-5(2,3)4/h1-5H,(H4,14,15,19)(H3,16,17,20,21);1H3,(H,2,3,4)
• InChIKey: MHPIZTURFVSLTJ-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)O.C1=CC=C(C=C1)N=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N

Phenamil methanesulfonate（Cat No.:R022228）is a potent amiloride analog that selectively inhibits epithelial sodium channels (ENaC), thereby blocking sodium reabsorption across epithelial tissues. By targeting ENaC, it modulates fluid and electrolyte transport, making it valuable for studying renal physiology, blood pressure regulation, and pulmonary fluid balance. Phenamil is also widely used in cardiovascular and pulmonary research to investigate hypertension, edema, and cystic fibrosis–related ion channel dysfunction. Its high affinity and specificity provide researchers with a reliable tool to dissect ENaC-mediated processes and explore therapeutic strategies in cardiovascular and respiratory disorders.