For research use only. Not for therapeutic Use.
PHD-1-IN-1（Cat No.:I015461）is a selective small-molecule inhibitor of prolyl hydroxylase domain-containing protein 1 (PHD1), an oxygen-sensing enzyme that hydroxylates hypoxia-inducible factor (HIF) under normoxia, marking it for degradation. By inhibiting PHD1, this compound stabilizes HIF and enhances transcription of hypoxia-responsive genes involved in angiogenesis, erythropoiesis, and metabolic adaptation. PHD-1-IN-1 is widely applied in studies of ischemia, anemia, cancer biology, and oxygen homeostasis, providing a tool to probe PHD1-specific pathways. Its selectivity makes it valuable for distinguishing PHD1’s role from other PHD isoforms in therapeutic research.
| CAS Number | 2009343-14-8 |
| Synonyms | 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile |
| Molecular Formula | C13H8N4 |
| Purity | ≥95% |
| IUPAC Name | 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile |
| InChI | InChI=1S/C13H8N4/c14-8-10-4-6-11(7-5-10)12-2-1-3-13-15-9-16-17(12)13/h1-7,9H |
| InChIKey | DEYMFBHALUHGST-UHFFFAOYSA-N |
| SMILES | C1=CC2=NC=NN2C(=C1)C3=CC=C(C=C3)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
