Phanquinone

• CAT Number: M010397
• CAS Number: 84-12-8
• Molecular Formula: C12H6N2O2
• Molecular Weight: 210.19
• Purity: ≥95%
• Synonyms: 4,7-phenanthroline-5,6-dione;phanquinone;phanquone;4,7-phenanthrolene-5,6-quinone;enthohex;entobex;C-11925;Ciba 11925
• Storage: -20°C
• IUPAC Name: 4,7-phenanthroline-5,6-dione
• InChI: InChI=1S/C12H6N2O2/c15-11-9-7(3-1-5-13-9)8-4-2-6-14-10(8)12(11)16/h1-6H
• InChIKey: VLPADTBFADIFKG-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=O)C(=O)C3=C2C=CC=N3)N=C1

Phanquinone (Cat No.: M010397) is a synthetic organic compound classified as a quinone derivative, known for its antimicrobial and antiprotozoal properties. Structurally related to naphthoquinones, it functions by interfering with cellular respiration and redox cycling in target organisms. Phanquinone has been studied for its potential use in treating parasitic infections such as schistosomiasis and trypanosomiasis. Its electrophilic nature enables it to react with nucleophilic biomolecules, making it useful in biochemical research. Additionally, it serves as a redox-active agent in various chemical applications.

Reference

1: Gioia MG, Gatti R, Minarini A. LC determination of leuprolide component amino
acids in injectable solution by phanquinone pre-column derivatization labelling
procedure. J Pharm Biomed Anal. 2005 Apr 29;37(5):1135-41. PubMed PMID: 15862697.

2: Gatti R, Gioia MG, Andreatta P, Pentassuglia G. HPLC-fluorescence
determination of amino acids in pharmaceuticals after pre-column derivatization
with phanquinone. J Pharm Biomed Anal. 2004 Apr 16;35(2):339-48. PubMed PMID:
15063467.

3: Gotti R, Gioia MG, Gatti R, Cavrini V. Phanquinone as a suitable
derivatization reagent in micellar electrokinetic chromatography and HPLC
analysis of amino acids. J Sep Sci. 2006 Jun;29(9):1259-67. PubMed PMID:
16833084.

4: Gatti R, Gioia MG. Liquid chromatographic fluorescence determination of amino
acids in plasma and urine after derivatization with phanquinone. Biomed
Chromatogr. 2008 Feb;22(2):207-13. PubMed PMID: 18004736.

5: Chaiyabutr N, Tesprateep T, Loypetjra P, Pichaicharnarong A. Urinary bladder
effects after oral dosages of the antidiarrhoeal drug
(clioquinol/phanquinone/oxyphenonium bromide) in experimental dogs. J Med Assoc
Thai. 1985 Dec;68(12):649-53. PubMed PMID: 2937868.