PHA 568487 free base

• CAT Number: I011680
• CAS Number: 527680-56-4
• Molecular Formula: C16H20N2O3
• Molecular Weight: 288.34
• Purity: ≥95%
• Synonyms: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide
• InChI: InChI=1S/C16H20N2O3/c19-16(17-13-10-18-5-3-11(13)4-6-18)12-1-2-14-15(9-12)21-8-7-20-14/h1-2,9,11,13H,3-8,10H2,(H,17,19)/t13-/m0/s1
• InChIKey: LUVXHMJTVXZFPD-ZDUSSCGKSA-N
• SMILES: C1CN2CCC1C(C2)NC(=O)C3=CC4=C(C=C3)OCCO4

PHA 568487 free base (Cat No.: I011680) is a selective agonist of the 5-hydroxytryptamine 2B (5-HT₂B) serotonin receptor, a G protein–coupled receptor involved in regulating vascular tone, cardiac function, and gastrointestinal activity. By activating 5-HT₂B, it stimulates downstream signaling pathways such as phospholipase C activation and intracellular calcium release. PHA 568487 is used in pharmacological research to study 5-HT₂B receptor function, ligand selectivity, and serotonergic signaling. The free base form offers flexibility in formulation for in vitro and in vivo studies in cardiovascular and neuropharmacology research.

Reference

[1]. F Barclay Shilliday, et al. Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. Drug Metab Lett. 2010 Aug;4(3):162-72.
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[2]. Zhenying Han, et al. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov;131(4):498-508.
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[3]. Lorena Colás, et al. In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia. Glia. 2018 Aug;66(8):1611-1624.
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