For research use only. Not for therapeutic Use.
PHA-543613（Cat No.:I008724）is a potent, orally active, and brain-penetrant agonist selective for the α7 nicotinic acetylcholine receptor (α7 nAChR), with a Ki of 8.8 nM . It exhibits high selectivity over other receptor subtypes, including α3β4, α1β1γδ, α4β2, and 5-HT3 receptors . PHA-543613 has demonstrated efficacy in improving cognitive deficits in preclinical models of Alzheimer’s disease and schizophrenia by enhancing sensory gating and memory functions . Additionally, it has shown neuroprotective effects by reducing microglial activation and promoting neuronal survival in models of neuroinflammation . These properties position PHA-543613 as a promising candidate for research into treatments for neurocognitive disorders.
| CAS Number | 478149-53-0 |
| Synonyms | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide |
| Molecular Formula | C15H17N3O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide |
| InChI | InChI=1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1 |
| InChIKey | IPKZCLGGYKRDES-ZDUSSCGKSA-N |
| SMILES | C1CN2CCC1[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
