PGN-9856

• CAT Number: I034554
• CAS Number: 863704-91-0
• Molecular Formula: C21H15F2NO4
• Molecular Weight: 383.34
• Purity: ≥95%
• Synonyms: 2-[3-[[2-fluoro-5-(3-fluorophenyl)benzoyl]amino]phenoxy]acetic acid
• InChI: InChI=1S/C21H15F2NO4/c22-15-4-1-3-13(9-15)14-7-8-19(23)18(10-14)21(27)24-16-5-2-6-17(11-16)28-12-20(25)26/h1-11H,12H2,(H,24,27)(H,25,26)
• InChIKey: HZJWJNHYKNSGAT-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)F)C2=CC(=C(C=C2)F)C(=O)NC3=CC(=CC=C3)OCC(=O)O

PGN-9856 (Cat No.: I034554) is a selective small-molecule agonist of the prostaglandin D₂ receptor 2 (DP2 or CRTH2), which plays a key role in allergic inflammation and immune cell recruitment, particularly involving eosinophils, basophils, and Th2 lymphocytes. Initially developed for the treatment of allergic diseases such as asthma, atopic dermatitis, and rhinitis, PGN-9856 modulates immune responses by activating DP2 signaling pathways. Although its clinical development status remains limited, it serves as a valuable tool in studying prostaglandin-mediated immune modulation and inflammatory disease mechanisms.

Reference

[1]. Coleman RA, et al. The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. Br J Pharmacol. 2019 Mar;176(5):687-698.
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