PGLa TFA

• CAT Number: I046002
• Molecular Formula: C90H163F3N26O24S
• Molecular Weight: 2082.47
• Purity: ≥95%

PGLa TFA(CAT: I046002) is a 21–residue antimicrobial peptide belonging to the magainin family, originally isolated from frog skin secretions. Structurally, PGLa begins with a glycine and terminates with a leucine amide, adopting an amphipathic α-helical conformation that enables membrane disruption. It exhibits broad-spectrum bacteriostatic activity, with MIC values of 64 mg/L against Staphylococcus aureus and 32 mg/L against Escherichia coli. As a natural defense peptide, PGLa is widely used in studies of host defense mechanisms, membrane biophysics, and antibiotic peptide design, providing a valuable model for the development of novel antimicrobial therapeutics.

Reference

[1]. Bechinger B, et al. Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J. 1998 Feb;74(2 Pt 1):981-7.
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[2]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27.
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