PFI-90

• CAT Number: I044415
• CAS Number: 53995-62-3
• Molecular Formula: C11H10N4O
• Molecular Weight: 214.22
• Purity: ≥95%
• Synonyms: N’-pyridin-2-ylpyridine-2-carbohydrazide
• IUPAC Name: N'-pyridin-2-ylpyridine-2-carbohydrazide
• InChI: InChI=1S/C11H10N4O/c16-11(9-5-1-3-7-12-9)15-14-10-6-2-4-8-13-10/h1-8H,(H,13,14)(H,15,16)
• InChIKey: GCZPXNWBXDWHKM-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)C(=O)NNC2=CC=CC=N2

PFI-90（Cat No.:I044415）is a potent, selective inhibitor of BRPF1 (bromodomain and PHD finger-containing protein 1), a scaffolding protein critical for chromatin remodeling and epigenetic regulation. By targeting the bromodomain of BRPF1, PFI-90 disrupts its interaction with acetylated histones, thereby modulating gene expression linked to cell proliferation and differentiation. This compound is particularly useful in studying the role of BRPF1 in leukemia, neurological disorders, and other diseases driven by epigenetic dysregulation. PFI-90 offers a valuable chemical probe for investigating chromatin biology and developing targeted epigenetic therapies in cancer and beyond.