For research use only. Not for therapeutic Use.
PFI-653（Cat No.:I018008）is a selective inhibitor of lysine demethylase 5 (KDM5/JARID1) family enzymes, which regulate histone H3K4 methylation and play critical roles in epigenetic control of gene expression. By blocking KDM5 activity, PFI-653 increases global H3K4 methylation levels, thereby modulating transcriptional programs linked to cell differentiation, proliferation, and survival. It is widely applied in cancer epigenetics research to investigate the role of histone demethylases in tumor progression and therapy resistance. PFI-653 provides a valuable chemical probe for exploring epigenetic mechanisms and developing novel therapeutic strategies.
| CAS Number | 2173134-00-2 |
| Synonyms | 8-oxa-2-azaspiro[4.5]decan-2-yl-[2-(pyrazin-2-ylmethylamino)pyrimidin-5-yl]methanone |
| Molecular Formula | C18H22N6O2 |
| Purity | ≥95% |
| IUPAC Name | 8-oxa-2-azaspiro[4.5]decan-2-yl-[2-(pyrazin-2-ylmethylamino)pyrimidin-5-yl]methanone |
| InChI | InChI=1S/C18H22N6O2/c25-16(24-6-1-18(13-24)2-7-26-8-3-18)14-9-21-17(22-10-14)23-12-15-11-19-4-5-20-15/h4-5,9-11H,1-3,6-8,12-13H2,(H,21,22,23) |
| InChIKey | VGRLXWFIXGZRMS-UHFFFAOYSA-N |
| SMILES | C1CN(CC12CCOCC2)C(=O)C3=CN=C(N=C3)NCC4=NC=CN=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
