PF-9363

• CAT Number: I045394
• CAS Number: 2569009-58-9
• Molecular Formula: C20H20N4O6S
• Molecular Weight: 444.46
• Purity: ≥95%

PF-9363 (Cat No.: I045394) is an investigational small-molecule inhibitor targeting dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. By blocking DHODH activity, PF-9363 disrupts nucleotide synthesis, leading to impaired DNA replication and cell proliferation—especially in rapidly dividing cells such as cancer cells and activated immune cells. It is being studied for potential applications in oncology and autoimmune diseases. PF-9363 is primarily used in preclinical research to evaluate DHODH as a therapeutic target and explore metabolic vulnerabilities in disease.

Reference

[1]. Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation

[2]. WO2020254946