For research use only. Not for therapeutic Use.
PF-4693627(CAT: I011988) is a potent, selective, and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with an IC₅₀ of 3 nM, developed for the treatment of inflammation associated with osteoarthritis (OA) and rheumatoid arthritis (RA). It inhibits mPGES-1 with IC₅₀ values of 180 nM (HWB-1483 cells) and 6 nM (human fetal fibroblasts), and demonstrates strong activity in LPS-stimulated human whole blood assays (IC₅₀ = 109 nM). In vivo, oral PF-4693627 (10 mg/kg) reduces PGE₂ production by 63% in guinea pig inflammation models. Pharmacokinetic studies in rats show 59% oral bioavailability and a modest half-life (t₁/₂ = 3.7 h).
| CAS Number | 1312815-93-2 |
| Synonyms | 1-[5-chloro-6-(4-chlorophenyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamide |
| Molecular Formula | C26H29Cl2N3O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[5-chloro-6-(4-chlorophenyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamide |
| InChI | InChI=1S/C26H29Cl2N3O3/c27-19-6-4-17(5-7-19)21-13-24-23(14-22(21)28)30-26(34-24)31-10-8-18(9-11-31)25(33)29-20-3-1-2-16(12-20)15-32/h4-7,13-14,16,18,20,32H,1-3,8-12,15H2,(H,29,33)/t16-,20-/m0/s1 |
| InChIKey | CPDNPVKDQXLYHO-JXFKEZNVSA-N |
| SMILES | C1CC(CC(C1)NC(=O)C2CCN(CC2)C3=NC4=C(O3)C=C(C(=C4)Cl)C5=CC=C(C=C5)Cl)CO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
