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PF-3644022 - CAS 1276121-88-0

PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). PF-3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM).

Catalog Number: R057373

CAS Number: 1276121-88-0

Molecular Formula: C21H18N4OS

Molecular Weight:374.46

Purity: ≥95%

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Synonym

Synonyms(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5’,6’:4,5]thieno[3,2-f]quinolin-8-one;

Property

Molecular Formula: C21H18N4OS
Molecular Weight374.46
Target:MAPKAPK
SolubilitySoluble in DMSO > 10 mM
Purity≥95%
StorageStore at +4C

Computed Descriptor

InChIInChI=1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1
InChIKeyCMWRPDHVGMHLSZ-GFCCVEGCSA-N
SMILESO=C1C2=C(C3=C(S2)C=CC4=NC(C5=CC=C(C)N=C5)=CC=C34)NC[C@@H](C)N1