For research use only. Not for therapeutic Use.
PF-07220060（Cat No.:I044399）is an investigational, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1), developed by Pfizer for the treatment of cancers harboring IDH1 mutations. By targeting this mutant enzyme, PF-07220060 aims to reduce the production of the oncometabolite 2-hydroxyglutarate, which disrupts cellular metabolism and epigenetic regulation. This compound is being explored for its potential in treating solid tumors and hematologic malignancies, including cholangiocarcinoma and glioma. Its specificity for mutant IDH1 offers a precision medicine approach, minimizing off-target effects and potentially improving outcomes for patients with IDH1-driven cancers.
| CAS Number | 2380321-51-5 |
| Synonyms | (3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(2-hydroxypropan-2-yl)-3-propan-2-ylbenzimidazol-5-yl]pyrimidin-2-yl]amino]oxan-3-ol |
| Molecular Formula | C22H27ClFN5O3 |
| Purity | ≥95% |
| IUPAC Name | (3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(2-hydroxypropan-2-yl)-3-propan-2-ylbenzimidazol-5-yl]pyrimidin-2-yl]amino]oxan-3-ol |
| InChI | InChI=1S/C22H27ClFN5O3/c1-11(2)29-16-8-12(7-14(24)19(16)27-20(29)22(3,4)31)18-13(23)9-25-21(28-18)26-15-5-6-32-10-17(15)30/h7-9,11,15,17,30-31H,5-6,10H2,1-4H3,(H,25,26,28)/t15-,17-/m1/s1 |
| InChIKey | QYJLBHRAPDJOSO-NVXWUHKLSA-N |
| SMILES | CC(C)N1C2=C(C(=CC(=C2)C3=NC(=NC=C3Cl)N[C@@H]4CCOC[C@H]4O)F)N=C1C(C)(C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
