For research use only. Not for therapeutic Use.
PF-07208254(CAT: I040569) is a potent and selective inhibitor of branched-chain α-keto acid dehydrogenase kinase (BDK), an enzyme that negatively regulates the catabolism of branched-chain amino acids (BCAAs). By inhibiting BDK, PF-07208254 enhances BCAA oxidation, leading to improved metabolic flexibility and energy homeostasis. In preclinical studies, PF-07208254 has demonstrated significant efficacy in improving cardiometabolic parameters in mouse models, including reductions in lipid accumulation, enhanced insulin sensitivity, and improved cardiac function. This compound serves as a valuable tool for investigating BDK-related metabolic regulation and holds promise for therapeutic development targeting metabolic disorders such as obesity, insulin resistance, and cardiovascular disease.
| CAS Number | 2573122-40-2 |
| Synonyms | 6-chloro-2-fluorothieno[3,2-b]thiophene-5-carboxylic acid |
| Molecular Formula | C7H2ClFO2S2 |
| Purity | ≥95% |
| IUPAC Name | 6-chloro-2-fluorothieno[3,2-b]thiophene-5-carboxylic acid |
| InChI | InChI=1S/C7H2ClFO2S2/c8-4-5-2(1-3(9)13-5)12-6(4)7(10)11/h1H,(H,10,11) |
| InChIKey | UXMBSHHPPVOPJU-UHFFFAOYSA-N |
| SMILES | C1=C(SC2=C1SC(=C2Cl)C(=O)O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
