For research use only. Not for therapeutic Use.
PF-06939999 (Cat No.: I045454) is a potent, selective inhibitor of ketohexokinase (KHK), the first enzyme in fructose metabolism that phosphorylates fructose to fructose-1-phosphate. By blocking KHK activity, PF-06939999 reduces fructose catabolism, thereby lowering uric acid production and potentially mitigating metabolic disturbances linked to excessive fructose intake. It is investigated for therapeutic applications in metabolic diseases such as non-alcoholic fatty liver disease (NAFLD), obesity, and gout. PF-06939999 also serves as a research tool for studying fructose metabolism, energy balance, and related metabolic and cardiovascular disorders.
| CAS Number | 2159123-14-3 |
| Synonyms | (1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methylpyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol |
| Molecular Formula | C22H23F3N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H23F3N4O3/c1-10-11-3-5-29(22(11)28-9-27-10)15-7-17(20(31)19(15)30)32-16-6-13(21(24)25)18(23)12-2-4-26-8-14(12)16/h3,5-6,9,15,17,19-21,26,30-31H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1 |
| InChIKey | HBGHQRGHFNTSDP-DJABAAGCSA-N |
| SMILES | CC1=C2C=CN(C2=NC=N1)C3CC(C(C3O)O)OC4=C5CNCCC5=C(C(=C4)C(F)F)F |
| Reference | [1]. Adli M. Combinatorial drug treatment of cancer. WO2020198601A1. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
