PF-06426779

• CAT Number: I045499
• CAS Number: 1817628-40-2
• Molecular Formula: C17H18FN3O4
• Molecular Weight: 347.34
• Purity: ≥95%
• Synonyms: 1-[[(2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide
• InChI: InChI=1S/C17H18FN3O4/c1-8-12(21-16(23)14(8)18)7-25-17-10-6-13(24-2)11(15(19)22)5-9(10)3-4-20-17/h3-6,8,12,14H,7H2,1-2H3,(H2,19,22)(H,21,23)/t8-,12+,14-/m0/s1
• InChIKey: GISRWBROCYNDME-PELMWDNLSA-N
• SMILES: CC1C(NC(=O)C1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N

PF-06426779 (Cat No.: I045499) is a selective, brain-penetrant inhibitor of the T-type calcium channel Cav3.2, a voltage-gated channel involved in regulating neuronal excitability, pain transmission, and sleep–wake cycles. By blocking Cav3.2, PF-06426779 reduces calcium influx, modulating neuronal firing and neurotransmitter release. It has been investigated for potential therapeutic applications in neuropathic pain, epilepsy, and sleep disorders. PF-06426779 is used in neuroscience and pharmacology research to study T-type calcium channel physiology and develop targeted treatments for conditions involving Cav3.2-mediated hyperexcitability and abnormal calcium signaling.

Reference

[1]. Lee KL, et, al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragme
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