For research use only. Not for therapeutic Use.
PF-05381941 (Cat No.: I034478) is an investigational small-molecule inhibitor developed to target Bromodomain and Extra-Terminal (BET) proteins, which regulate transcription of oncogenes and inflammatory mediators. By binding to BET bromodomains, PF-05381941 disrupts protein–chromatin interactions, leading to suppression of aberrant gene expression. It has been explored in preclinical and clinical studies for its potential in cancer therapy, autoimmune diseases, and inflammatory disorders. As a selective epigenetic modulator, PF-05381941 provides insights into transcriptional control and offers promise as a targeted therapeutic strategy.
| CAS Number | 1474022-02-0 |
| Synonyms | 1-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-3-(3-methyl-4-pyridin-4-yloxyphenyl)urea |
| Molecular Formula | C27H26N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H26N6O2/c1-18-14-20(8-9-23(18)35-22-10-12-29-13-11-22)30-26(34)31-25-16-24(27(2,3)4)32-33(25)21-7-5-6-19(15-21)17-28/h5-16H,1-4H3,(H2,30,31,34) |
| InChIKey | BVCVUQMOUMAXKQ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)NC(=O)NC2=CC(=NN2C3=CC=CC(=C3)C#N)C(C)(C)C)OC4=CC=NC=C4 |
| Reference | [1]. Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
