PF-04802367

• CAT Number: I045528
• CAS Number: 1962178-27-3
• Molecular Formula: C16H16ClN5O3
• Molecular Weight: 361.78
• Purity: ≥95%
• Synonyms: 5-(3-chloro-4-methoxyphenyl)-N-[3-(1,2,4-triazol-1-yl)propyl]-1,3-oxazole-4-carboxamide
• InChI: InChI=1S/C16H16ClN5O3/c1-24-13-4-3-11(7-12(13)17)15-14(20-10-25-15)16(23)19-5-2-6-22-9-18-8-21-22/h3-4,7-10H,2,5-6H2,1H3,(H,19,23)
• InChIKey: RQFYFNAGNBUGFC-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=C(N=CO2)C(=O)NCCCN3C=NC=N3)Cl

PF-04802367 (Cat No.: I045528) is a selective, brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), an enzyme that degrades cyclic AMP (cAMP). By blocking PDE4 activity, PF-04802367 elevates intracellular cAMP levels, thereby enhancing signaling pathways linked to cognition and memory. It was originally investigated by Pfizer as a therapeutic candidate for Alzheimer’s disease and other cognitive disorders. Preclinical studies demonstrated improvements in synaptic plasticity and learning, making PF-04802367 a valuable compound for exploring PDE4 inhibition in neurodegenerative research.

Reference

[1]. Steven H Liang, et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9601-5.
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[2]. Vadim Bernard-Gauthier, et al. Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery. J Med Chem. 2019 Nov 14;62(21):9600-9617.
[Content Brief]