For research use only. Not for therapeutic Use.
PF-04745637（Cat No.:I008662）is a potent, selective small-molecule antagonist of the C-C chemokine receptor 2 (CCR2), developed by Pfizer. By blocking CCR2–CCL2 interactions, it inhibits monocyte recruitment and inflammatory signaling, processes implicated in autoimmune diseases, metabolic disorders, and cancer. PF-04745637 has been investigated for therapeutic potential in conditions such as rheumatoid arthritis, atherosclerosis, and tumor microenvironment modulation. Its high selectivity and pharmacological profile make it a valuable tool for studying chemokine-driven immune responses. In research, PF-04745637 helps elucidate CCR2-mediated pathways and supports drug discovery targeting chronic inflammation and cancer.
| CAS Number | 1917294-46-2 |
| Synonyms | 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]-3-phenylpropyl]cyclopentane-1-carboxamide |
| Molecular Formula | C27H32ClF3N2O2 |
| Purity | ≥95% |
| IUPAC Name | 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]-3-phenylpropyl]cyclopentane-1-carboxamide |
| InChI | InChI=1S/C27H32ClF3N2O2/c28-22-10-8-21(9-11-22)25(12-4-5-13-25)24(34)32-19-23(18-20-6-2-1-3-7-20)33-16-14-26(35,15-17-33)27(29,30)31/h1-3,6-11,23,35H,4-5,12-19H2,(H,32,34) |
| InChIKey | PAEBEJVPSADOMC-UHFFFAOYSA-N |
| SMILES | C1CCC(C1)(C2=CC=C(C=C2)Cl)C(=O)NCC(CC3=CC=CC=C3)N4CCC(CC4)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
