For research use only. Not for therapeutic Use.
PF-03654764（Cat No.:I014993）is a potent histamine H3 receptor antagonist developed by Pfizer. By blocking presynaptic H3 autoreceptors, it increases histamine release and enhances neurotransmitter activity, including acetylcholine, norepinephrine, and dopamine. This pharmacological action links PF-03654764 to potential therapeutic applications in neurological and psychiatric disorders such as narcolepsy, attention-deficit hyperactivity disorder (ADHD), cognitive impairment, and sleep–wake regulation. Preclinical and clinical studies have explored its efficacy in modulating alertness and cognitive function. As a selective H3 antagonist, it also serves as a valuable research tool in neuropharmacology and drug discovery.
| CAS Number | 935840-35-0 |
| Synonyms | 3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutane-1-carboxamide |
| Molecular Formula | C20H28F2N2O |
| Purity | ≥95% |
| IUPAC Name | 3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutane-1-carboxamide |
| InChI | InChI=1S/C20H28F2N2O/c1-14(2)12-23-19(25)16-10-20(22,11-16)17-6-5-15(18(21)9-17)13-24-7-3-4-8-24/h5-6,9,14,16H,3-4,7-8,10-13H2,1-2H3,(H,23,25) |
| InChIKey | DJRDLCHHQYHQQK-UHFFFAOYSA-N |
| SMILES | CC(C)CNC(=O)C1CC(C1)(C2=CC(=C(C=C2)CN3CCCC3)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
