PF-03654746 Tosylate

• CAT Number: I046127
• CAS Number: 1039399-17-1
• Molecular Formula: C25H32F2N2O4S
• Molecular Weight: 494.59
• Purity: ≥95%
• Synonyms: N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide;4-methylbenzenesulfonic acid
• InChI: InChI=1S/C18H24F2N2O.C7H8O3S/c1-2-21-17(23)14-10-18(20,11-14)15-6-5-13(16(19)9-15)12-22-7-3-4-8-22;1-6-2-4-7(5-3-6)11(8,9)10/h5-6,9,14H,2-4,7-8,10-12H2,1H3,(H,21,23);2-5H,1H3,(H,8,9,10)
• InChIKey: IKAYTZLLIWAEDV-UHFFFAOYSA-N
• SMILES: CCNC(=O)C1CC(C1)(C2=CC(=C(C=C2)CN3CCCC3)F)F.CC1=CC=C(C=C1)S(=O)(=O)O

PF-03654746 tosylate（Cat No.:I046127）is a selective antagonist of the adenosine A2A receptor, developed by Pfizer for neurological and psychiatric research. The A2A receptor is highly expressed in the brain, particularly in the basal ganglia, where it regulates dopaminergic signaling. By blocking A2A activity, PF-03654746 modulates neurotransmission, making it a candidate for treating Parkinson’s disease, cognitive dysfunction, and sleep disorders. Preclinical and early clinical studies suggested benefits in improving motor function and alertness. As a research tool, it provides insights into adenosine receptor biology and therapeutic targeting.