PF-02413873

• CAT Number: I008649
• CAS Number: 936345-35-6
• Molecular Formula: C18H21N3O3S
• Molecular Weight: 359.44
• Purity: ≥95%
• Synonyms: 4-[3-cyclopropyl-5-methyl-1-(methylsulfonylmethyl)pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile
• InChI: InChI=1S/C18H21N3O3S/c1-11-7-15(8-12(2)16(11)9-19)24-18-13(3)21(10-25(4,22)23)20-17(18)14-5-6-14/h7-8,14H,5-6,10H2,1-4H3
• InChIKey: QSFGZNVRVZHUGV-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC(=C1C#N)C)OC2=C(N(N=C2C3CC3)CS(=O)(=O)C)C

PF-02413873 (Cat No.: I008649) is a selective nonsteroidal antagonist of the progesterone receptor (PR), developed as a research tool to explore hormone signaling and reproductive biology. By blocking PR activity, it helps researchers study the regulation of ovulation, endometrial function, and hormone-dependent diseases such as endometriosis and certain cancers. PF-02413873 is also investigated in preclinical models to assess its potential in contraceptive strategies. While not advanced for clinical use, it remains an important compound for understanding progesterone-mediated pathways in biomedical research.

Reference

[1]. Howe DC, et, al. The translational efficacy of a nonsteroidal progesterone receptor antagonist, 4-[3-cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on endometrial growth in macaque and human. J Pharmacol
[Content Brief]

[2]. Bungay PJ, et, al. Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist. Drug Metab Dispos. 2011 Aug;39(8):1396-405.
[Content Brief]