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Perphenazine

Perphenazine

  • CAT Number: A000002
  • CAS Number: 58-39-9
  • Molecular Formula: C21H26ClN3OS
  • Molecular Weight: 404
  • Purity: ≥95%
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Perphenazine(cas 58-39-9) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions.

Catalog Number A000002
CAS Number 58-39-9
Molecular Formula

C21H26ClN3OS

Purity 95%
Target Dopamine Receptor
Solubility Soluble in DMSO
Storage Store at -20°C
InChIKey RGCVKNLCSQQDEP-UHFFFAOYSA-N
Reference

1: Hartung B, Sampson S, Leucht S. Perphenazine for schizophrenia. Cochrane
Database Syst Rev. 2015 Mar 6;(3):CD003443. doi: 10.1002/14651858.CD003443.pub3.
Review. PubMed PMID: 25749632.</br>
2: Tardy M, Huhn M, Engel RR, Leucht S. Perphenazine versus low-potency
first-generation antipsychotic drugs for schizophrenia. Cochrane Database Syst
Rev. 2014 Oct 7;(10):CD009369. doi: 10.1002/14651858.CD009369.pub2. Review.
PubMed PMID: 25290157.</br>
3: Marco I, Cabezón O, Mentaberre G, Fernández-Sirera L, Casas-Díaz E,
Fernandez-Aguilar X, López-Olvera JR, Serrano E, Navarro-Gonzalez N, Lavín S,
Manteca X. Effect of perphenazine enanthate in Pyrenean chamois (Rupicapra
pyrenaica). J Zoo Wildl Med. 2013 Dec;44(4):1083-5. PubMed PMID: 24450074.</br>

4: Henao JP, Peperzak KA, Lichvar AB, Orebaugh SL, Skledar SJ, Pippi MA, Williams
BA. Extrapyramidal symptoms following administration of oral perphenazine 4 or
8&#8202;mg: an 11-year retrospective analysis. Eur J Anaesthesiol. 2014
Apr;31(4):231-5. doi: 10.1097/EJA.0000000000000048. PubMed PMID: 24503705; PubMed
Central PMCID: PMC4365999.</br>
5: Park YM. Prolonged Drug-Drug Interaction between Terbinafine and Perphenazine.
Psychiatry Investig. 2012 Dec;9(4):422-4. doi: 10.4306/pi.2012.9.4.422. Epub 2012
Nov 12. PubMed PMID: 23251210; PubMed Central PMCID: PMC3521122.</br>
6: Activation of PP2A by perphenazine induces apoptosis in T-ALL. Cancer Discov.
2014 Mar;4(3):OF14. doi: 10.1158/2159-8290.CD-RW2014-017. Epub 2014 Jan 23.
PubMed PMID: 24596208.

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