PERK-IN-5

• CAT Number: I043975
• CAS Number: 2616821-91-9
• Molecular Formula: C25H26F2N4O3
• Molecular Weight: 468.50
• Purity: ≥95%
• Synonyms: 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-propan-2-ylpyridine-3-carboxamide
• InChI: InChI=1S/C25H26F2N4O3/c1-4-14-9-19(31-25(34)22(32)15-7-17(26)11-18(27)8-15)5-6-20(14)16-10-21(23(28)29-12-16)24(33)30-13(2)3/h5-13,22,32H,4H2,1-3H3,(H2,28,29)(H,30,33)(H,31,34)/t22-/m1/s1
• InChIKey: YNDQMKBAYRFBMW-JOCHJYFZSA-N
• SMILES: CCC1=C(C=CC(=C1)NC(=O)[C@@H](C2=CC(=CC(=C2)F)F)O)C3=CC(=C(N=C3)N)C(=O)NC(C)C

PERK-IN-5（Cat No.:I043975）is a selective inhibitor of PERK (Protein Kinase R-like Endoplasmic Reticulum Kinase), an enzyme involved in the unfolded protein response (UPR). PERK is activated under conditions of endoplasmic reticulum stress and plays a key role in maintaining cellular homeostasis, but its dysregulation is associated with various diseases, including cancer, neurodegenerative disorders, and diabetes. By inhibiting PERK, PERK-IN-5 helps modulate the UPR, potentially reducing cell survival in stressed tumor cells while enhancing the effectiveness of other cancer therapies. This compound is being investigated for its therapeutic potential in oncology and neurodegenerative diseases.