For research use only. Not for therapeutic Use.
PERK-IN-4（Cat No.:R055225）is a selective inhibitor of PERK (PKR-like endoplasmic reticulum kinase), a key regulator of the unfolded protein response (UPR) pathway activated during ER stress. By targeting the kinase activity of PERK, PERK-IN-4 suppresses eIF2α phosphorylation, thereby modulating downstream stress responses including translational arrest and pro-apoptotic signaling. This compound is a valuable research tool for investigating ER stress-related diseases such as cancer, neurodegeneration, and diabetes. PERK-IN-4 enables precise exploration of the role of PERK signaling in cellular homeostasis, stress adaptation, and therapeutic targeting of the UPR.
| CAS Number | 1337531-89-1 |
| Synonyms | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone |
| Molecular Formula | C24H19F4N5O |
| Purity | ≥95% |
| IUPAC Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone |
| InChI | InChI=1S/C24H19F4N5O/c1-32-11-18(21-22(29)30-12-31-23(21)32)14-2-3-19-15(9-14)4-5-33(19)20(34)8-13-6-16(24(26,27)28)10-17(25)7-13/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,29,30,31) |
| InChIKey | PXVQGBJMIQCDEX-UHFFFAOYSA-N |
| SMILES | CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC(=C5)F)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
