For research use only. Not for therapeutic Use.
PERK-IN-2(CAT: I017527) is a highly potent and selective inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK), with an IC₅₀ of 0.2 nM. In cellular assays, PERK-IN-2 effectively suppresses PERK autophosphorylation in A549 cells with IC₅₀ values ranging from 0.03–0.1 μM following 2-hour treatment. By targeting PERK, a key mediator of the unfolded protein response (UPR), this compound is a valuable tool for studying endoplasmic reticulum stress, integrated stress response signaling, and their roles in cancer, neurodegeneration, and metabolic diseases. PERK-IN-2 offers researchers a precise pharmacological probe for dissecting PERK-dependent pathways and exploring therapeutic potential in stress-related disorders.
| CAS Number | 1337531-83-5 |
| Synonyms | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(2,3,5-trifluorophenyl)ethanone |
| Molecular Formula | C23H18F3N5O |
| Purity | ≥95% |
| IUPAC Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(2,3,5-trifluorophenyl)ethanone |
| InChI | InChI=1S/C23H18F3N5O/c1-30-10-16(20-22(27)28-11-29-23(20)30)12-2-3-18-13(6-12)4-5-31(18)19(32)8-14-7-15(24)9-17(25)21(14)26/h2-3,6-7,9-11H,4-5,8H2,1H3,(H2,27,28,29) |
| InChIKey | JCUSVFKWUQBVHH-UHFFFAOYSA-N |
| SMILES | CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=C(C(=CC(=C5)F)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
