Pep2m, myristoylated TFA

• CAT Number: I044318
• Molecular Formula: C65H119F3N18O16S
• Molecular Weight: 1497.83
• Purity: ≥95%
• IUPAC Name: (2S)-5-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-(tetradecanoylamino)hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylsulfanylbutanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C63H118N18O14S.C2HF3O2/c1-7-8-9-10-11-12-13-14-15-16-17-29-51(84)74-42(25-18-21-33-64)55(87)77-45(28-24-36-71-63(69)70)56(88)78-46(32-37-96-6)58(90)76-44(27-20-23-35-66)59(91)81-52(39(2)3)61(93)73-41(5)53(85)75-43(26-19-22-34-65)57(89)80-48(38-50(68)83)60(92)72-40(4)54(86)79-47(62(94)95)30-31-49(67)82;3-2(4,5)1(6)7/h39-48,52H,7-38,64-66H2,1-6H3,(H2,67,82)(H2,68,83)(H,72,92)(H,73,93)(H,74,84)(H,75,85)(H,76,90)(H,77,87)(H,78,88)(H,79,86)(H,80,89)(H,81,91)(H,94,95)(H4,69,70,71);(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,52-;/m0./s1
• InChIKey: LKKZFINUWDZEHG-HVXFLXQCSA-N
• SMILES: CCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)O.C(=O)(C(F)(F)F)O

Pep2m, myristoylated TFA（Cat No.:I044318）is a synthetic, cell-permeable peptide designed to inhibit the interaction between importin-β and nuclear localization signal (NLS)-containing proteins, thereby blocking nuclear import. The myristoylation at the N-terminus enhances membrane association and cellular uptake, while the peptide sequence mimics a nuclear transport substrate. It is widely used in molecular biology and cancer research to study nucleocytoplasmic trafficking, transcriptional regulation, and signal transduction. The TFA (trifluoroacetate) salt form improves solubility and stability. Pep2m is a valuable tool for modulating nuclear transport and investigating nuclear signaling mechanisms in cells.