PEMPIDINE Tartrate

• CAT Number: T000025
• CAS Number: 546-48-5
• Molecular Formula: C14H27NO6
• Molecular Weight: 305.371
• Purity: ≥95%
• Synonyms: 1,2,2,6,6-pentamethylpiperidine d-tartrate.
• Solubility: water, ethanol.
• Storage: store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 6.56 ml), stable for 1-2 days at 20°C.
• Related CAS: 79-55-0 (base), 6152-93-8 (tosilate).
• IUPAC Name: (2R,3R)-2,3-dihydroxybutanedioic acid;1,2,2,6,6-pentamethylpiperidine
• InChI: InChI=1S/C10H21N.C4H6O6/c1-9(2)7-6-8-10(3,4)11(9)5;5-1(3(7)8)2(6)4(9)10/h6-8H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
• InChIKey: AAFNEINEQRQMTF-LREBCSMRSA-N
• SMILES: CC1(CCCC(N1C)(C)C)C.C(C(C(=O)O)O)(C(=O)O)O

PEMPIDINE Tartrate(CAS 546-48-5) is a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Antihypertensive. Good penetration of biological membranes. Monocyclic analog of TEMECHINE.

Piperidine derivative,<!–C10H21N .C4H6O6–>, synthetic.

For comparative information see the attached tables. Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.

Produces a slowly developing voltage-dependent block of ionoforetically activated cholinergic currents of the lobster gastric mill [3, 4].

CNS activity: see the attached table.

35 mg/kg increases ATP and decreases AMP [5]. Modulation of Dopamine release [6]. Increases IP level (Sherman).

Reference

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– Mader et al., /Voltage dependent blocade of a crustacean muscle/, J. Exp. Biol. (1980). 88:147-159

– Lingle, J. Physio. (1983) (London). 339:419-437

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– Rapier C. et al., Neuropharm. (1990). 54(3):937-945

– Spinks et al., Nature (1958). 181:1397

– Corne et al., Brit.J.Pharm. (1958). 13(5):501-520

– Spinks et al., Brit.J.Pharm. (1958). 13(4):501-520