PEMPIDINE Tartrate

  • CAT Number: T000025
  • CAS Number: 546-48-5
  • Molecular Formula: C14H27NO6
  • Molecular Weight: 305.371
  • Purity: ≥95%
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<p>
PEMPIDINE Tartrate(CAS 546-48-5) is a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Antihypertensive. Good penetration of biological membranes. Monocyclic analog of TEMECHINE.</p>
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Piperidine derivative,<!–C<sub>10</sub>H<sub>21</sub>N .C<sub>4</sub>H<sub>6</sub>O<sub>6</sub>–>, synthetic.<br />
<p>
<em>For comparative information see the attached tables.</em> Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation.<br />
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Produces a slowly developing voltage-dependent block of ionoforetically activated cholinergic currents of the lobster gastric mill [3, 4].<br />
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CNS activity: see the attached table.<br />
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35 mg/kg increases ATP and decreases AMP [5]. Modulation of Dopamine release [6]. Increases IP level (Sherman).</p>
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Catalog Number T000025
CAS Number 546-48-5
Synonyms

1,2,2,6,6-pentamethylpiperidine d-tartrate.

Molecular Formula

C14H27NO6

Purity 95%
Solubility water, ethanol.
Storage store at room temperature. Solution for use: dissolve in water: 10-3M (2 mg in 6.56 ml), stable for 1-2 days at 20°C.
Related CAS 79-55-0 (base), 6152-93-8 (tosilate).
IUPAC Name (2R,3R)-2,3-dihydroxybutanedioic acid;1,2,2,6,6-pentamethylpiperidine
InChI InChI=1S/C10H21N.C4H6O6/c1-9(2)7-6-8-10(3,4)11(9)5;5-1(3(7)8)2(6)4(9)10/h6-8H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
InChIKey AAFNEINEQRQMTF-LREBCSMRSA-N
SMILES CC1(CCCC(N1C)(C)C)C.C(C(C(=O)O)O)(C(=O)O)O
Reference

– Lee J.E. et al., <i>Nature</i> (1958) 181:1717<br />
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– Romano C. et al, <i>Psychopharmacologie</i> (1981) 74(4):310-315<br />
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– Mader et al., /Voltage dependent blocade of a crustacean muscle/, <i>J. Exp. Biol.</i> (1980). 88:147-159<br />
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– Lingle, <i>J. Physio.</i> (1983) (London). 339:419-437<br />
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– Tichonenko V.M., Farm.Toxikol.(Kiev) (1980). (13):109-125 (1978); [p.42-44 Engl.]., CA 93: 762<br />
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– Rapier C. et al., <i>Neuropharm.</i> (1990). 54(3):937-945<br />
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– Spinks et al., <i>Nature</i> (1958). 181:1397<br />
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– Corne et al., <i>Brit.J.Pharm.</i> (1958). 13(5):501-520<br />
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– Spinks et al., <i>Brit.J.Pharm.</i> (1958). 13(4):501-520<br />
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