PDK4-IN-1 hydrochloride

• CAT Number: I016175
• CAS Number: 2310262-11-2
• Molecular Formula: C₂₂H₂₀ClN₃O₂
• Molecular Weight: 393.87
• Purity: ≥95%

PDK4-IN-1 hydrochloride (CAT: I016175) is a hydrochloride salt form of PDK4-IN-1, a selective inhibitor of pyruvate dehydrogenase kinase 4 (PDK4). PDK4 is an enzyme that regulates the activity of pyruvate dehydrogenase complex (PDC), a key enzyme involved in glucose metabolism. By inhibiting PDK4, PDK4-IN-1 promotes the activity of PDC, leading to increased glucose oxidation and energy production. PDK4-IN-1 has shown potential as a therapeutic agent for metabolic disorders such as diabetes and obesity. Further studies are ongoing to explore its pharmacological applications and therapeutic benefits.

Reference

[1]. Lee D, et al. Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem. 2019 Jan 24;62(2):575-588.