For research use only. Not for therapeutic Use.
PDGFR Tyrosine Kinase Inhibitor III（Cat No.:I044132）is a selective small-molecule inhibitor targeting platelet-derived growth factor receptors (PDGFR-α and PDGFR-β), which are critical mediators of cell proliferation, survival, and angiogenesis. By blocking PDGFR autophosphorylation and downstream signaling pathways, this inhibitor suppresses tumor growth, fibrosis, and abnormal vascular remodeling. It is widely used in cancer and fibrotic disease research to explore PDGFR-driven pathologies and therapeutic mechanisms. PDGFR Tyrosine Kinase Inhibitor III is a valuable pharmacological tool for studying receptor tyrosine kinase inhibition and evaluating targeted strategies in oncology and tissue repair models.
| CAS Number | 205254-94-0 |
| Synonyms | 4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide |
| Molecular Formula | C27H27N5O4 |
| Purity | ≥95% |
| IUPAC Name | 4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide |
| InChI | InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) |
| InChIKey | INTPTKHSGKBHHW-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=O)NC4=CC=C(C=C4)OC5=CC=CC=C5)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
