For research use only. Not for therapeutic Use.
PDD00031705(CAT: I016816) is a benzimidazolone-based inhibitor of poly(ADP-ribose) glycohydrolase (PARG), the primary enzyme responsible for hydrolyzing poly(ADP-ribose) chains and regulating DNA repair pathways. Classified as a cell-inactive probe, PDD00031705 serves as a negative control in studies evaluating PARG function and inhibitor selectivity. While it demonstrates limited biological activity, modest cytotoxicity has been observed in HeLa cells, emphasizing the need for cautious interpretation in cellular assays. This compound is particularly valuable as part of chemical biology toolkits, enabling researchers to distinguish on-target versus off-target effects when validating novel PARG inhibitors in DNA damage response and cancer research.
| CAS Number | 2032096-45-8 |
| Synonyms | 1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-N-methyl-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)benzimidazole-5-sulfonamide |
| Molecular Formula | C20H22N6O3S3 |
| Purity | ≥95% |
| IUPAC Name | 1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-N-methyl-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)benzimidazole-5-sulfonamide |
| InChI | InChI=1S/C20H22N6O3S3/c1-12-17(30-13(2)23-12)10-25-15-6-5-14(32(28,29)24(4)20(3)7-8-20)9-16(15)26(19(25)27)18-21-11-22-31-18/h5-6,9,11H,7-8,10H2,1-4H3 |
| InChIKey | KWGUETFSHQZXMA-UHFFFAOYSA-N |
| SMILES | CC1=C(SC(=N1)C)CN2C3=C(C=C(C=C3)S(=O)(=O)N(C)C4(CC4)C)N(C2=O)C5=NC=NS5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
