For research use only. Not for therapeutic Use.
PDD00017272（Cat No.:I034321）is a potent, selective small-molecule inhibitor of USP7 (ubiquitin-specific protease 7), a deubiquitinating enzyme that regulates protein stability in key cellular pathways. By blocking USP7 activity, PDD00017272 promotes degradation of oncogenic and regulatory proteins, thereby impacting p53 signaling, DNA repair, and immune responses. Researchers use this compound to explore the role of ubiquitin-dependent proteostasis in cancer biology and other diseases. Its high specificity and effectiveness make it a valuable tool for studying deubiquitination mechanisms and advancing therapeutic strategies targeting the ubiquitin–proteasome system.
| CAS Number | 1945950-20-8 |
| Synonyms | 1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide |
| Molecular Formula | C23H25N5O4S3 |
| Purity | ≥95% |
| IUPAC Name | 1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide |
| InChI | InChI=1S/C23H25N5O4S3/c1-13-20(34-15(3)25-13)12-27-19-6-5-17(35(31,32)26-23(4)7-8-23)9-18(19)21(29)28(22(27)30)11-16-10-24-14(2)33-16/h5-6,9-10,26H,7-8,11-12H2,1-4H3 |
| InChIKey | QOEXRJYTAZZRPL-UHFFFAOYSA-N |
| SMILES | CC1=C(SC(=N1)C)CN2C3=C(C=C(C=C3)S(=O)(=O)NC4(CC4)C)C(=O)N(C2=O)CC5=CN=C(S5)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
