PD 168368

• CAT Number: I008618
• CAS Number: 204066-82-0
• Molecular Formula: C31H34N6O4
• Molecular Weight: 554.64
• Purity: ≥95%
• Synonyms: (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide
• InChI: InChI=1S/C31H34N6O4/c1-30(19-22-20-33-26-10-4-3-9-25(22)26,36-29(39)35-23-12-14-24(15-13-23)37(40)41)28(38)34-21-31(16-6-2-7-17-31)27-11-5-8-18-32-27/h3-5,8-15,18,20,33H,2,6-7,16-17,19,21H2,1H3,(H,34,38)(H2,35,36,39)/t30-/m0/s1
• InChIKey: AFDXUTWMFMAQJO-PMERELPUSA-N
• SMILES: CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC3(CCCCC3)C4=CC=CC=N4)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-]

PD 168368 (Cat No.: I008618) is a potent, selective neurokinin-2 (NK2) receptor antagonist used in pharmacological and biomedical research. By blocking NK2 receptors, it inhibits the actions of neurokinin A, a tachykinin peptide involved in smooth muscle contraction, pain transmission, and inflammatory responses. PD 168368 has been applied in studies of airway physiology, gastrointestinal motility, and nociception, providing insights into tachykinin receptor signaling. Its high affinity and specificity make it a valuable tool for exploring NK2 receptor function, neuropeptide biology, and therapeutic target validation.

Reference

[1]. R R Ryan, et al. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. J Pharmacol Exp Ther. 1999 Sep;290(3):1202-11.
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[2]. K Tokita, et al. Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368. J Biol Chem. 2001 Jan 5;276(1):495-504.
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[3]. Igor A Schepetkin, et al. Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol. 2011 Jan;79(1):77-90.
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[4]. Hyun-Joo Park, et al. Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells. Int J Oncol. 2016 Sep;49(3):934-42.
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