PD-161570

• CAT Number: I012048
• CAS Number: 192705-80-9
• Molecular Formula: C26H35Cl2N7O
• Molecular Weight: 532.51
• Purity: ≥95%
• Synonyms: 1-tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]urea
• InChI: InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36)
• InChIKey: MKVMEJKNLUWFSQ-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C

PD-161570（Cat No.:I012048）is a potent small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase and related ErbB family kinases. By blocking EGFR phosphorylation and downstream signaling, it suppresses tumor cell proliferation, survival, and angiogenesis. PD-161570 has been widely studied in cancer research as a tool compound for evaluating EGFR-driven oncogenesis and resistance mechanisms. Its activity in preclinical models has provided insights into targeted therapy development, particularly in solid tumors such as lung and breast cancer. PD-161570 remains valuable in molecular pharmacology and oncology drug discovery.