PD-1/PD-L1-IN-9

• CAT Number: I045400
• CAS Number: 2628506-54-5
• Molecular Formula: C22H24N2O2
• Molecular Weight: 348.44
• Purity: ≥95%

PD-1/PD-L1-IN-9 (Cat No.: I045400) is a small-molecule inhibitor that disrupts the interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1, a critical immune checkpoint pathway exploited by tumors to evade immune surveillance. By blocking this interaction, PD-1/PD-L1-IN-9 promotes T cell activation and enhances antitumor immunity. It is studied as an alternative to monoclonal antibody therapies for cancer immunotherapy, offering potential advantages in oral bioavailability, tumor penetration, and manufacturing efficiency in preclinical models of solid and hematologic tumors.

Reference

[1]. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.
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