PD-1/PD-L1-IN-14

• CAT Number: I044061
• CAS Number: 2499965-12-5
• Molecular Formula: C24H24N4O2
• Molecular Weight: 400.47
• Purity: ≥95%
• Synonyms: 2-[[3-[[5-(2-methyl-3-phenylphenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol
• InChI: InChI=1S/C24H24N4O2/c1-17-21(19-8-3-2-4-9-19)11-6-12-22(17)23-27-28-24(30-23)26-20-10-5-7-18(15-20)16-25-13-14-29/h2-12,15,25,29H,13-14,16H2,1H3,(H,26,28)
• InChIKey: YBHXMLDVPTWSAS-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1C2=NN=C(O2)NC3=CC=CC(=C3)CNCCO)C4=CC=CC=C4

PD-1/PD-L1-IN-14（Cat No.:I044061）is a selective small-molecule inhibitor that disrupts the interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1, a critical immune checkpoint pathway that suppresses T-cell activation in the tumor microenvironment. By blocking this interaction, PD-1/PD-L1-IN-14 restores T-cell function and promotes anti-tumor immunity. This compound is particularly valuable in cancer immunotherapy research, especially in studies aiming to overcome immune evasion by tumors. PD-1/PD-L1-IN-14 offers a non-antibody-based approach for modulating checkpoint inhibition, supporting the development of next-generation immuno-oncology therapies with improved accessibility and pharmacokinetics.