For research use only. Not for therapeutic Use.
PD-1-IN-24（Cat No.:I044530）is a small-molecule inhibitor designed to block the interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1, a key immune checkpoint pathway exploited by tumors to evade immune surveillance. By inhibiting PD-1 signaling, PD-1-IN-24 restores T cell activation and enhances anti-tumor immune responses. This compound offers a non-antibody approach to checkpoint blockade, with potential advantages in oral bioavailability, tumor penetration, and manufacturing. PD-1-IN-24 is primarily used in cancer immunotherapy research to explore novel strategies for reversing T cell exhaustion and improving immune-mediated tumor clearance.
| CAS Number | 2360909-50-6 |
| Synonyms | (2S)-3-hydroxy-2-methyl-2-[[3-[(E)-2-(2-methyl-3-phenylphenyl)ethenyl]-4-(trifluoromethyl)phenyl]methylamino]propanoic acid |
| Molecular Formula | C27H26F3NO3 |
| Purity | ≥95% |
| IUPAC Name | (2S)-3-hydroxy-2-methyl-2-[[3-[(E)-2-(2-methyl-3-phenylphenyl)ethenyl]-4-(trifluoromethyl)phenyl]methylamino]propanoic acid |
| InChI | InChI=1S/C27H26F3NO3/c1-18-20(9-6-10-23(18)21-7-4-3-5-8-21)12-13-22-15-19(11-14-24(22)27(28,29)30)16-31-26(2,17-32)25(33)34/h3-15,31-32H,16-17H2,1-2H3,(H,33,34)/b13-12+/t26-/m0/s1 |
| InChIKey | ITARRJJJADSSAW-JYSHFMIGSA-N |
| SMILES | CC1=C(C=CC=C1C2=CC=CC=C2)/C=C/C3=C(C=CC(=C3)CN[C@@](C)(CO)C(=O)O)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
